منابع مشابه
Effect of Orthodontic Force on Dentinogenesis
265 Received February 25, 2010; revision accepted for publication June 22, 2010. doi:10.1620/tjem.221.265 Correspondence: Yin Ding, D.D.S., Ph. D., Department of Orthodontics, School of Stomatology, Fourth Military Medical University, 145 West Changle Road, Xi’an, Shaanxi 710032, China. e-mail: [email protected] (Xiangwei Kong); [email protected] (Yin Ding) Tohoku J. Exp. Med., 2010, 221, 26...
متن کاملL51P - A BMP2 variant with osteoinductive activity via inhibition of Noggin.
Bone morphogenetic proteins (BMP) have to be applied at high concentrations to stimulate bone healing. The limited therapeutic efficacy may be due to the local presence of BMP antagonists such as Noggin. Thus, inhibiting BMP antagonists is an attractive therapeutic option. We hypothesized that the engineered BMP2 variant L51P stimulates osteoinduction by antagonizing Noggin-mediated inhibition ...
متن کاملNovel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling.
The secreted protein Noggin1 is an embryonic inducer that can sequester TGFβ cytokines of the BMP family with extremely high affinity. Owing to this function, ectopic Noggin1 can induce formation of the headless secondary body axis in Xenopus embryos. Here, we show that Noggin1 and its homolog Noggin2 can also bind, albeit less effectively, to ActivinB, Nodal/Xnrs and XWnt8, inactivation of whi...
متن کاملMutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN
Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two mutations (N445K,T) in patients with multiple synostosis syndrome (SYM1) in the BMP-related ligand GDF5. Functional studies of both mutants in chic...
متن کاملThe BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development.
Mouse cerberus-like encodes for a secreted factor of the Cerberus/Dan family. This molecule has neural inducing capabilities and can bind to BMP-4 and nodal molecules in the extracellular space. When cerberus-like is inactivated, its function may be compensated for another molecule, since no abnormalities can be observed in the mouse mutant. Compensation mechanisms have been shown to occur betw...
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ژورنال
عنوان ژورنال: Journal of Oral Biosciences
سال: 2020
ISSN: 1349-0079
DOI: 10.1016/j.job.2019.11.001